コンドウ　ミツコ   KONDOU Mitsuko   近藤　光子    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report.
掲載誌名	正式名：Respirology case reports 略　 称：Respirol Case Rep ISSNコード：20513380/20513380
掲載区分	国外
巻・号・頁	12(6),pp.e01403
著者・共著者	Arakawa Naoko†, Shiota Yuno, Onizawa Fumi, Miyata Fumi, Miyoshi Azusa, Akaba Tomohiro, Tsuji Mayoko, Arimura Ken, Yagi Osamitsu, Kondo Mitsuko, Katsura Hideki, Tagaya Etsuko
発行年月	2024/06
概要	A 46-year-old male was treated with corticosteroids for nonspecific interstitial pneumonia (NSIP). He was referred to our hospital and admitted for worsening dyspnea and diffuse ground-glass opacity on chest computed tomography (CT) during corticosteroid treatment. Gottron's sign was observed, and the patient was diagnosed with clinically amyopathic dermatomyositis on skin biopsy. We increased the corticosteroid dose and added immunosuppressive agents; however, the opacity on the chest CT worsened. Based on periodic-acid-Schiff-positive granular material in the bronchoalveolar lavage fluid and the presence of anti-GM-CSF antibodies, the patient was diagnosed with autoimmune pulmonary alveolar proteinosis (APAP). The concentration of anti-GM-CSF antibodies in preserved serum was also elevated when the patient was diagnosed with NSIP. Thus, we assumed that NSIP and APAP coexisted, and that APAP manifested during immunosuppressive therapy. When exacerbation is observed during the treatment of interstitial pneumonia with immunosuppressive agents, it is necessary to consider APAP.
DOI	10.1002/rcr2.1403
PMID	38863515