ナカバヤシ　アキラ   中林　章    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Outcomes of Ovulation Induction Aimed to Pregnancy in Eight Hypopituitarism Patients.
掲載誌名	正式名：Cureus 略　 称：Cureus ISSNコード：21688184/21688184
掲載区分	国外
巻・号・頁	16(4),pp.e58819
著者・共著者	Horibe Yu, Nakabayashi Akira, Murata Shuko, Hashimoto Tomomi, Tabata Tsutomu
発行年月	2024/04
概要	BACKGROUND:Female sex hormones work in concert. Gonadotropin-releasing hormone and ovulation-inducing agents are required in female patients with infertility owing to hormone dysregulation. Although drug-induced follicular development can be expected in patients with endogenous female hormone deficiency, data are lacking on the protocols and drugs used.METHODS:We retrospectively examined the success rates of ovulation induction, assisted reproductive technology, and pregnancy outcomes in 66 cycles of eight patients with pituitary insufficiency at our hospital.RESULTS:Ovulation occurred in 75.4% (49/66); 82.6% (38/46) of patients <40 years and 57.9% (11/19) of patients ≥40 years of age. Five of the eight patients became pregnant, and three delivered babies. The fertilization rate was 78% with in vitro fertilization, and the recombinant follicle-stimulating hormone usage was 3,717.1 ± 1,528.9 International Unit in hypopituitarism patients.CONCLUSION:Hypopituitarism patients can achieve ovulation, pregnancy, and delivery after optimal gonadotropin administration. Further studies are needed to determine the effects of gonadotropins on other pituitary hormones, such as growth hormones.
DOI	10.7759/cureus.58819
PMID	38784333