ナカバヤシ アキラ
中林 章 所属 医学部 医学科(東京女子医科大学病院) 職種 准教授 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Outcomes of Ovulation Induction Aimed to Pregnancy in Eight Hypopituitarism Patients. |
掲載誌名 | 正式名:Cureus 略 称:Cureus ISSNコード:21688184/21688184 |
掲載区分 | 国外 |
巻・号・頁 | 16(4),pp.e58819 |
著者・共著者 | Horibe Yu, Nakabayashi Akira, Murata Shuko, Hashimoto Tomomi, Tabata Tsutomu |
発行年月 | 2024/04 |
概要 | BACKGROUND:Female sex hormones work in concert. Gonadotropin-releasing hormone and ovulation-inducing agents are required in female patients with infertility owing to hormone dysregulation. Although drug-induced follicular development can be expected in patients with endogenous female hormone deficiency, data are lacking on the protocols and drugs used.METHODS:We retrospectively examined the success rates of ovulation induction, assisted reproductive technology, and pregnancy outcomes in 66 cycles of eight patients with pituitary insufficiency at our hospital.RESULTS:Ovulation occurred in 75.4% (49/66); 82.6% (38/46) of patients <40 years and 57.9% (11/19) of patients ≥40 years of age. Five of the eight patients became pregnant, and three delivered babies. The fertilization rate was 78% with in vitro fertilization, and the recombinant follicle-stimulating hormone usage was 3,717.1 ± 1,528.9 International Unit in hypopituitarism patients.CONCLUSION:Hypopituitarism patients can achieve ovulation, pregnancy, and delivery after optimal gonadotropin administration. Further studies are needed to determine the effects of gonadotropins on other pituitary hormones, such as growth hormones. |
DOI | 10.7759/cureus.58819 |
PMID | 38784333 |