ヒグチ　サトシ   HIGUCHI Satoshi   樋口　諭    所属   医学部 医学科（東京女子医科大学病院）    職種   寄附部門講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Diagnosis and Management of Complex Reentrant Arrhythmias Involving the His-Purkinje System.
掲載誌名	正式名：Arrhythmia & electrophysiology review 略　 称：Arrhythm Electrophysiol Rev ISSNコード：20503369/20503369
掲載区分	国外
巻・号・頁	10(3),pp.190-197
著者・共著者	Sung Raphael K, Boyden Penelope A, Higuchi Satoshi, Scheinman Melvin
発行年月	2021/10
概要	The His-Purkinje system is a network of bundles and fibres comprised of specialised cells that allow for coordinated, synchronous activation of the ventricles. Although the histology and physiology of the His-Purkinje system have been studied for more than a century, its role in ventricular arrhythmias has recently been discovered with the ongoing elucidation of the mechanisms leading to both benign and life-threatening arrhythmias. Studies of Purkinje-cell electrophysiology show multiple mechanisms responsible for ventricular arrhythmias, including enhanced automaticity, triggered activity and reentry. The variation in functional properties of Purkinje cells in different areas of the His-Purkinje system underlie the propensity for reentry within Purkinje fibres in structurally normal and abnormal hearts. Catheter ablation is an effective therapy in nearly all forms of reentrant arrhythmias involving Purkinje tissue. However, identifying those at risk of developing fascicular arrhythmias is not yet possible. Future research is needed to understand the precise molecular and functional changes resulting in these arrhythmias.
DOI	10.15420/aer.2021.22
PMID	34777824