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イチハラ アツヒロ
ICHIHARA Atsuhiro
市原 淳弘 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study. |
| 掲載誌名 | 正式名：Cytokine 略 称：Cytokine ISSNコード：10960023/10434666 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 178,pp.156583 |
| 著者・共著者 | TSUJI Mayoko†, KONDO Mitsuko, SATO Yasuto, MIYOSHI Azusa, MIYATA Fumi, ARIMURA Ken, YAMASHITA Kaoru, MORIMOTO Satoshi, YANAGISAWA Naoko, ICHIHARA Atsuhiro, TAGAYA Etsuko |
| 発行年月 | 2024/06 |
| 概要 | BACKGROUND AND OBJECTIVE:The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity and mortality. This study aimed to investigate the clinical significance of serum vascular endothelial growth factor A (VEGF-A) in COVID-19 patients and its association with disease severity and pulmonary injury.METHODS:We prospectively collected data from 71 hospitalized COVID-19 patients between June 2020 and January 2021. Patients were classified as either mild or severe based on their oxygen requirements during hospitalization. Serum VEGF-A levels were measured using an ELISA kit.RESULTS:In comparison to mild cases, significantly elevated serum VEGF-A levels were observed in severe COVID-19 patients. Furthermore, VEGF-A levels exhibited a positive correlation with white blood cell count, neutrophil count, and lymphocyte count. Notably, serum surfactant protein-D (SP-D), an indicator of alveolar epithelial cell damage, was significantly higher in patients with elevated VEGF-A levels.CONCLUSION:These results suggest that elevated serum VEGF-A levels could serve as a prognostic biomarker for COVID-19 as it is indicative of alveolar epithelial cell injury caused by SARS-CoV-2 infection. Additionally, we observed a correlation between VEGF-A and neutrophil activation, which plays a role in the immune response during endothelial cell injury, indicating a potential involvement of angiogenesis in disease progression. Further research is needed to elucidate the underlying mechanisms of VEGF-A elevation in COVID-19. |
| DOI | 10.1016/j.cyto.2024.156583 |
| PMID | 38554499 |