ヤマシタ　カオル   Yamashita Kaoru   山下　薫    所属   医学部 医学科（東京女子医科大学病院）    職種   嘱託医師
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study.
掲載誌名	正式名：Cytokine 略　 称：Cytokine ISSNコード：10960023/10434666
掲載区分	国外
巻・号・頁	178,pp.156583
著者・共著者	TSUJI Mayoko†, KONDO Mitsuko, SATO Yasuto, MIYOSHI Azusa, MIYATA Fumi, ARIMURA Ken, YAMASHITA Kaoru, MORIMOTO Satoshi, YANAGISAWA Naoko, ICHIHARA Atsuhiro, TAGAYA Etsuko
発行年月	2024/06
概要	BACKGROUND AND OBJECTIVE:The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity and mortality. This study aimed to investigate the clinical significance of serum vascular endothelial growth factor A (VEGF-A) in COVID-19 patients and its association with disease severity and pulmonary injury.METHODS:We prospectively collected data from 71 hospitalized COVID-19 patients between June 2020 and January 2021. Patients were classified as either mild or severe based on their oxygen requirements during hospitalization. Serum VEGF-A levels were measured using an ELISA kit.RESULTS:In comparison to mild cases, significantly elevated serum VEGF-A levels were observed in severe COVID-19 patients. Furthermore, VEGF-A levels exhibited a positive correlation with white blood cell count, neutrophil count, and lymphocyte count. Notably, serum surfactant protein-D (SP-D), an indicator of alveolar epithelial cell damage, was significantly higher in patients with elevated VEGF-A levels.CONCLUSION:These results suggest that elevated serum VEGF-A levels could serve as a prognostic biomarker for COVID-19 as it is indicative of alveolar epithelial cell injury caused by SARS-CoV-2 infection. Additionally, we observed a correlation between VEGF-A and neutrophil activation, which plays a role in the immune response during endothelial cell injury, indicating a potential involvement of angiogenesis in disease progression. Further research is needed to elucidate the underlying mechanisms of VEGF-A elevation in COVID-19.
DOI	10.1016/j.cyto.2024.156583
PMID	38554499