イシヅカ　ツトム   Ishidzuka Tsutomu   石塚　敏    所属   その他 その他    職種   臨床検査副技師長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Serum level of full-length connective tissue growth factor reflects liver fibrosis stage in patients with Fontan-associated liver disease.
掲載誌名	正式名：PloS one 略　 称：PLoS One ISSNコード：19326203/19326203
掲載区分	国外
巻・号・頁	19(1),pp.e0296375
著者・共著者	KOGISO Tomomi†, TAKAYANAGI Kayo, ISHIZUKA Tsutomu, OTSUKA Motoyuki, INAI Kei, OGASAWARA Yuri, HORIUCHI Kentaro, TANIAI Makiko, TOKUSHIGE Katsutoshi
発行年月	2024/01
概要	BACKGROUND:Chronic liver disease leads to liver fibrosis, and an accurate diagnosis of the fibrosis stage is crucial for medical management. Connective tissue growth factor (CTGF) is produced by endothelial cells and platelets and plays a central role in inducing fibrosis in various organs. In the present study, we tested the validity of measuring the serum levels of two types of CTGF to estimate the biopsy-confirmed liver fibrosis stage.METHODS:We used two detection antibodies targeting the N- and C-terminal of CTGF to measure the serum levels of two forms of CTGF consisting of its full length and its N-terminal fragment. We analyzed the level of CTGF (via enzyme-linked immunosorbent assay) and the liver fibrosis stage in 38 patients with Fontan-associated liver disease (FALD) (26 cases of which were diagnosed pathologically). Correlations were determined by multivariate analysis and the area under the receiver operating characteristic curve. The 65 patients with nonalcoholic fatty liver disease (NAFLD) were included as a disease control group for examination.RESULTS:Full-length CTGF was significantly inversely correlated with liver fibrosis in patients with FALD. Although the platelet count was also associated with the liver fibrosis stage, full-length CTGF was more closely correlated with the fibrosis stage. Furthermore, the level of full-length CTGF was inversely associated with high central venous pressure. Conversely, the serum level of CTGF was not correlated with the fibrosis stage in NAFLD.CONCLUSION:The serum level of full-length CTGF may be useful for estimating the liver fibrosis stage in patients with FALD.
DOI	10.1371/journal.pone.0296375
PMID	38166061