アカギリ　サトミ   AKAGIRI Satomi
  赤桐　里美
   所属   医学研究科 医学研究科 (医学部医学科をご参照ください)
   職種   特任助教
Article types Original article
Language English
Peer review Peer reviewed
Title Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism.
Journal Formal name：Biochemical and biophysical research communications
Abbreviation：Biochem Biophys Res Commun
ISSN code：10902104/0006291X
Domestic / ForeginForegin
Volume, Issue, Page 413(2),pp.330-335
Author and coauthor Aoi Wataru, Naito Yuji, Hang Liu Po, Uchiyama Kazuhiko, Akagiri Satomi, Mizushima Katsura, Yoshikawa Toshikazu
Publication date 2011/09/23
Summary Fatty liver is known as the initial stage in nonalcoholic fatty liver disease. Epidemiological studies have shown that regular exercise prevents accumulation of hepatic lipids, although the underlying mechanism is unclear. The purpose of this study was to investigate the effect of exercise on fatty liver associated with hepatic lipid metabolism. KK/Ta mice (6 weeks old) were divided into sedentary and exercise groups and compared with sedentary Balb/c mice. All the mice were fed a high-sucrose diet for 12 weeks. The KK/Ta mice in the exercise group performed a treadmill running exercise at 20 m/min for 30 min (3 times per week). Twelve weeks of regular exercise suppressed the accumulation of lipid in the liver, along with reduction in the level of lipid in the plasma. The levels of carnitine palmitoyl transferase II, acyl-coenzyme A dehydrogenase, and trifunctional enzyme, which are rate-limiting enzymes in fatty acid oxidation in the liver, were elevated by exercise. In addition, the expression of fatty acid synthase, a key lipogenetic enzyme, was reduced by exercise. Furthermore, regular exercise decreased the expression of heat shock protein 47, a marker of hepatic fibrosis, in the liver. Our results suggest that regular exercise prevents fatty liver via improvement of hepatic lipid metabolism.
DOI 10.1016/j.bbrc.2011.08.097
PMID 21893033