タカギ　リヨウ   TAKAGI Riyou
  高木　亮
   所属   医学研究科 医学研究科 (医学部医学科をご参照ください)
   職種   助教
Article types Original article
Language English
Peer review Peer reviewed
Title Effect of basic fibroblast growth factor with collagen/gelatin fixture in a rabbit model of nasal septum perforation.
Journal Formal name：Regenerative therapy
Abbreviation：Regen Ther
ISSN code：23523204/23523204
Domestic / ForeginForegin
Volume, Issue, Page 25,pp.387-394
Author and coauthor TAKIZAWA Yuki†, MORINO Tsunetaro, TAKAGI Ryo, OTORI Nobuyoshi, KOJIMA Hiromi, YAMATO Masayuki*
Publication date 2024/03
Summary INTRODUCTION:The treatment of nasal septum perforation solely by surgical intervention presents significant challenges. This study evaluated the effect of basic fibroblast growth factor (bFGF) in combination with collagen/gelatin on wound healing of nasal septum perforation in a rabbit animal model.METHODS:A nasal septum perforation rabbit model was created. bFGF was added to a collagen/gelatin fixture and placed adjacent to the perforation, which is a complete defect. The rabbits were divided into three groups: the sham group that underwent the surgical procedure only, bFGF (-) group that received collagen/gelatin fixture without bFGF, and bFGF(+) group that received collagen/gelatin fixture with bFGF. The dimensions of the perforations were measured after 4 weeks, and the septum was subjected to histological examination.RESULTS:All perforations remained open in the sham group (closure rate: 20.4%-83.1%). The closure rates of the bFGF(-) and bFGF(+) groups were 49.4%-68.8% and 72.7%-100%, respectively. No significant difference was noted in the closure rates between the sham and bFGF(-) groups; however, significant differences were observed between the sham and bFGF(+) groups, and the bFGF(-) and bFGF(+) groups (p < 0.05), indicating that bFGF promoted perforation closure.CONCLUSIONS:The study demonstrated that bFGF with collagen/gelatin carrier promoted wound healing in a rabbit model of nasal septum perforation.
DOI 10.1016/j.reth.2024.02.001
PMID 38425672