ホシノ　ジユンイチ   Hoshino Jiyun'ichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読なし
表題	正常範囲の血清レニンで発症した悪性腎硬化症の1例(A case of malignant nephrosclerosis occurring with serum renin in the normal range)
掲載誌名	正式名：CEN case reports. 略　 称：CEN Case Rep ISSNコード：21924449
掲載区分	国外
出版社	シュプリンガー・ジャパン(株)
巻・号・頁	12(1),pp.116-121
著者・共著者	Sawamura Masato, Sawa Naoki, Oshima Yoichi, Ikuma Daisuke, Yamanouchi Masayuki, Hayami Noriko, Sekine Akinari, Mizuno Hiroki, Hasegawa Eiko, Suwabe Tatsuya, Hoshino Junichi, Kono Kei, Kinowaki Keiichi, Ohashi Kenichi, Ubara Yoshifumi
発行年月	2023/02
概要	A 37-year-old Japanese man was admitted to our hospital for evaluation of severe hypertension and visual impairment. His serum creatinine was 4.16 mg/dL. Plasma renin activity was normal (2.7 ng/mL/h), but plasma aldosterone concentration was elevated (27.2 ng/dL). A kidney biopsy showed concentric subendothelial edematous thickening of the arterioles (onion skin pattern) with luminal narrowing or obstruction, and malignant nephrosclerosis was diagnosed. Antihypertensive therapies, including an angiotensin II receptor blocker and spironolactone, were administered and effectively preserved kidney function and normalized blood pressure. This case indicates that hyperaldosteronemia in the presence of normal renin levels might also cause malignant hypertension.
DOI	10.1007/s13730-022-00726-x
文献番号	2024062480
PMID	36038752