オオツボ　テンペイ   Ootsubo Tenpei   大坪　天平    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	日本語
査読の有無	査読あり
表題	[Depression during interferon therapy in renal cell cancer patients--comparison with chronic hepatitis C patients].
掲載誌名	正式名：Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 略　 称：Nihon Hinyokika Gakkai Zasshi ISSNコード：00215287/00215287
掲載区分	国内
巻・号・頁	91(9),611-7頁
著者・共著者	Sakamoto H, Inoue K, Shimada M, Yoshida H, Otsubo T, Miyaoka H, Kamizima K, Ishii M, Mitamura K
発行年月	2000/09
概要	BACKGROUND AND PURPOSE:Depression is well known as one of the psychiatric complications of interferon (IFN) therapy in patients with chronic active hepatitis C. We compared the psychiatric status during interferon therapy between patients with renal cell cancer (RCC) and those with chronic active hepatitis C.METHODS:The psychiatric status of 40 patients with renal cell cancer, 36 who were subjected to radical nephrectomy and 4 who were not because of the presence of distant metastasis and other complicated underlying diseases, was assessed by psychiatrists before and at 2, 4, 12 and 24 weeks after the start of IFN therapy according to the major depressive episode diagnostic criteria listed in the DSM-III-R and the Hamilton Depression Scale (HDS). The mental aspect was measured using the Eysenk Personality Questionnaire (EPQ) before IFN therapy, and the results were compared with those obtained in 85 hepatitis C patients evaluated according to the same protocol for psychiatric assessment.RESULTS:Eight of the 40 patients were diagnosed as having depression before IFN therapy and 5 of them became even more depressed 2 weeks after the start of IFN therapy. Nine patients were found to be depressed after the start of IFN therapy, 7 of them were diagnosed before 4 weeks of therapy. All the patients needed treatment for depression: discontinuation of IFN therapy in 4, decrement of the IFN dose in 8, and psychiatric drug medication in 13. The patients who suffered from depression had significantly higher scores in neuroticism (EPQ) before IFN therapy than those who did not become depressed. There was no difference in age, sex or cancer stage between the two groups. The occurrence of depression in RCC patients was the same as that observed in hepatitis C patients receiving IFN therapy. But in RCC patients the depressive state was diagnosed earlier and was more severe than that observed in hepatitis C patients.CONCLUSION:Urologists should be aware of the psychiatric symptoms o
DOI	10.5980/jpnjurol1989.91.611
PMID	11068424