オオツボ　テンペイ   Ootsubo Tenpei   大坪　天平    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effect of high-dose milnacipran in patients with depression.
掲載誌名	正式名：Neuropsychiatric disease and treatment 略　 称：Neuropsychiatr Dis Treat ISSNコード：11766328/11766328
掲載区分	国外
巻・号・頁	3(5),pp.699-702
著者・共著者	Hayashi Masatoshi, Mimura Masaru, Otsubo Tempei, Kamijima Kunitoshi
発行年月	2007
概要	To investigate the antidepressant effect of high-dose milnacipran, we retrospectively compared three groups of inpatients with major depression; those who were given milnacipran >100-150 mg/day (high-dose milnacipran group), those treated with milnacipran at maximum doses of 50-100 mg/day (standard-dose milnacipran group), and those treated with paroxetine at maximum doses of 40 mg/day (paroxetine group). The Hamilton Depression Rating Scale (HAM-D) scores of the three groups showed significant decrease at discharge compared to the scores at admission, indicating improvement of depressive symptoms for each group. However, the mean HAM-D score on admission was significantly lower for the standard-dose milnacipran group than the high-dose milnacipran and paroxetine groups. Additional intermediate assessment of the high-dose milnacipran group showed that the effect of milnacipran was dose-dependent with an additional improvement when patients were increase from 100 to 150 mg/day. These results suggest that patients suffering from moderate to severe depression with relative high HAM-D scores may benefit from treatment with high-dose milnacipran.
PMID	19300602