ササキ　タカヒロ   Sasaki Takahiro   佐々木　孝寛    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Global axonal transport rates are unaltered in htau mice in vivo.
掲載誌名	正式名：Journal of Alzheimer's disease : JAD 略　 称：J Alzheimers Dis ISSNコード：18758908/13872877
掲載区分	国外
巻・号・頁	37(3),pp.579-86
著者・共著者	Yuan Aidong, Kumar Asok, Sasaki Takahiro, Duff Karen, Nixon Ralph A
発行年月	2013
概要	Microtubule-based axonal transport is believed to become globally disrupted in Alzheimer's disease in part due to alterations of tau expression or phosphorylation. We previously showed that axonal transport rates along retinal ganglion axons are unaffected by deletion of normal mouse tau or by overexpression of wild-type human tau. Here, we report that htau mice expressing 3-fold higher levels of human tau in the absence of mouse tau also display normal fast and slow transport kinetics despite the presence of abnormally hyperphosphorylated tau in some neurons. In addition, markers of slow transport (neurofilament light subunit) and fast transport (snap25) exhibit normal distributions along optic axons of these mice. These studies demonstrate that human tau overexpression, even when associated with a limited degree of tau pathology, does not necessarily impair general axonal transport function in vivo.
DOI	10.3233/JAD-130671
PMID	23948900