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ミズノ タカフミ
Mizuno Takafumi
水野 貴文 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Diastolic Dysfunction as a Positive Predictor of Recurrent Vascular Events in Patients With Noncardioembolic Stroke. |
| 掲載誌名 | 正式名：Stroke 略 称：Stroke ISSNコード：15244628/00392499 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 55(3),pp.595-603 |
| 著者・共著者 | Ishizuka Kentaro, Hoshino Takao, Mizuno Takafumi, Takahashi Shuntaro, Wako Sho, Arai Satoko, Toi Sono, Kitagawa Kazuo |
| 発行年月 | 2024/03 |
| 概要 | BACKGROUND:This study aimed to assess the effects of left ventricular diastolic dysfunction (LVDD) on vascular outcomes among patients with stroke of noncardioembolic origins.METHODS:This prospective observational study enrolled 563 patients with noncardioembolic stroke (mean age, 67.9 years; 66.7% men and 33.3% women individuals) registered in the Tokyo Women's Medical University Stroke Registry between 2013 and 2020. Then, patients were divided into the LVDD and non-LVDD groups. The primary outcome was a composite of major adverse cardiovascular events, including nonfatal stroke, nonfatal acute coronary syndrome, and vascular death 1 year after stroke onset. The effect of LVDD on vascular events was assessed using multivariable Cox regression analyses.RESULTS:A total of 130 (23.1%) patients had any grade of LVDD, and patients with LVDD had a higher risk of major adverse cardiovascular event at 1 year than those without LVDD (annual rate, 20.9% versus 10.8%; log-rank P=0.001). The multivariable Cox proportional hazards regression model demonstrated that the presence of LVDD was independently associated with the major adverse cardiovascular event risk (hazard ratio, 1.79 [95% CI, 1.02-3.12]; P=0.019). Furthermore, the LVDD grade was proportional to the risk of major adverse cardiovascular events and recurrent stroke.CONCLUSIONS:LVDD may be associated with further vascular events after a noncardioembolic stroke, suggesting the importance of LVDD evaluations in risk stratification and secondary prevention in patients with noncardioembolic stroke.REGISTRATION:URL: https://upload.umin.ac.jp; Unique identifier: UMIN000031913. |
| DOI | 10.1161/STROKEAHA.123.042548 |
| PMID | 38328918 |