アイボシ　ジユンイチ   Aiboshi Jiyun'ichi   相星　淳一    所属   医学部 医学科（附属八千代医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Association of SARS-CoV-2 RNA Copy Number with the COVID-19 Mortality Rate and Its Effect on the Predictive Performance of Mortality in Severe Cases
掲載誌名	正式名：Japanese journal of infectious diseases 略　 称：Jpn J Infect Dis ISSNコード：13446304/18842836
掲載区分	国外
巻・号・頁	75(5),pp.504-510
著者・共著者	Takahiro Mitsumura, Tsukasa Okamoto, Mizuho Tosaka, Takashi Yamana, Sho Shimada, Yuki Iijima, Rie Sakakibara, Sho Shibata, Takayuki Honda, Tsuyoshi Shirai, Masahiro Ishizuka, Junichi Aiboshi, Haruhiko Furusawa, Tomoya Tateishi, Meiyo Tamaoka, Hidenobu Shigemitsu, Hirokuni Arai, Yasuhiro Otomo, Shuji Tohda, Tatsuhiko Anzai, Kunihiko Takahashi, Shinsuke Yasuda, Yasunari Miyazaki
発行年月	2022/04/21
概要	Factors associated with mortality are important in the treatment of coronavirus disease 2019 (COVID-19). Polymerase chain reaction (PCR) is the gold standard for diagnosing COVID-19, which reflects the viral load in the upper respiratory tract. In total, 523 patients were enrolled in this study; of them, 441 and 75 patients underwent PCR testing of nasopharyngeal swabs and sputum samples, respectively, within 20 days from onset of COVID-19. We investigated the association between RNA copy number and the COVID-19 severity and mortality rate and its effect on the predictive performance for severity and mortality. RNA copy numbers in nasopharyngeal swabs were higher in the non-survivor group than in the survivor group. Multivariate logistic regression analysis identified that the high RNA copy number (≥9 log10 /swab) in nasopharyngeal swabs was a factor associated with mortality (odds ratio, 4.50; 95% confidence interval, 1.510–13.100; P = 0.008). Furthermore, adding RNA copy number (≥9 log10 /swab) in severe cases, adjusted by duration from onset to PCR, improved mortality predictive performance based on known factors. The RNA copy number is a factor associated with the mortality of patients with COVID-19 and can improve the predictive performance of mortality in severe cases.
DOI	10.7883/yoken.JJID.2022.080