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ホシノ ジユンイチ
Hoshino Jiyun'ichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Apolipoprotein E-associated Lipoprotein Glomerulo-tubulopathy. |
| 掲載誌名 | 正式名：Internal medicine (Tokyo, Japan) 略 称：Intern Med ISSNコード：09182918/13497235 |
| 巻・号・頁 | 62(15),pp.2209-2214 |
| 著者・共著者 | Tanimizu Hikaru, Hara Risa, Sekine Akinari, Inoue Noriko, Hasegawa Eiko, Tanaka Kiho, Kono Kei, Kinowaki Keiichi, Ohashi Kenichi, Okubo Minoru, Yamaguchi Yutaka, Kang Dedong, Honda Kazuho, Saito Takao, Sawa Naoki, Ubara Yoshifumi, Hoshino Junichi |
| 担当区分 | 最終著者,責任著者 |
| 発行年月 | 2023/08/01 |
| 概要 | A 32-year-old man was admitted for the evaluation of proteinuria (5.69 g/day). A light microscopic examination showed markedly dilated glomerular capillary loops with vacuolated areas in many glomeruli, and vacuolated areas were seen on peritubular capillaries in the tubulointerstitium. When electron microscopy specimens prepared by pre-fixation with glutaraldehyde and post-fixation with osmium tetroxide were used for oil red staining, the deposition was confirmed on the affected areas. A genetic analysis of apoE showed that the lipoprotein glomerulopathy was due to apoE-Sendai (Arg145Pro, p.R163P) heterozygosity, which was found in not only the patient but also his mother and twin brother. |
| DOI | 10.2169/internalmedicine.0834-22 |
| PMID | 37532513 |