オオサワ　シゲヒト   Oosawa Shigehito   大澤　重仁    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Mechanical properties of poly(N-acryloyl-glycinamide) hydrogels dependent on initiation number of the polymerization reaction
掲載誌名	正式名：ChemistrySelect ISSNコード：23656549
掲載区分	国外
出版社	Willey
巻・号・頁	9(6),pp.e202400244
総ページ数	8
著者・共著者	OSAWA Shigehito†*, AKIYAMA Yoshikatsu*
担当区分	筆頭著者,責任著者
発行年月	2024/02/12
概要	Hydrogels with polymer networks formed through physical interactions have received attention because of their post-moldability and self-healing properties upon physicochemical stimulation. Although hydrogels become fragile without covalent crosslinking, poly(N-acryloyl-glycinamide) (PNAGA) hydrogels, which are formed through hydrogen bonding among PNAGA molecules, have recently demonstrated exceptional strain. In this study, we prepared a series of PNAGA hydrogels with different molecular weights and constant weight concentrations of PNAGA. Stress–strain tests demonstrated that higher molecular weights of PNAGA promote extensibility. The swelling ability of the hydrogel also increased with higher molecular weights of PNAGA, suggesting that high molecular weights of PNAGA significantly increase the tolerability of hydrogels to shape change, which opens up new possibilities for developing robust hydrogels without the requirement for cross-linking. Although different behaviors were not observed with changes in the molecular weight, we achieved hydrogel re-construction using the PNAGA powder obtained from hydrogels, which demonstrates an advantage of such polymer networks based on hydrogen bonding. Regarding the healing ability of the cut surfaces, hydrogels with a lower molecular weight exhibited higher recoveries, probably owing to the high PNAGA mobility in the hydrogels. Finally, this study elucidates the importance of controlling the molecular weight when developing functional hydrogels.
DOI	10.1002/slct.202400244