オオサワ　シゲヒト   Oosawa Shigehito   大澤　重仁    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Low-adhesion and low-swelling hydrogel based on alginate and carbonated water to prevent temporary dilation of wound sites
掲載誌名	正式名：International journal of biological macromolecules 略　 称：Int J Biol Macromol ISSNコード：01418130/18790003
掲載区分	国外
出版社	Elsevier
巻・号・頁	254(3),pp.127928
著者・共著者	Teshima Ryota†*, Osawa Shigehito, Yoshikawa Miki, Kawano Yayoi*, Otsuka Hidenori, Hanawa Takehisa*
担当区分	2nd著者
発行年月	2024/01
概要	Hydrogel-based wound dressings have been developed for rapid wound healing; however, their adhesive properties have not been adequately investigated. Excessive adhesion to the skin causes wound expansion and pain when hydrogels absorb exudates and swell at wound sites. Herein, we developed a low-adhesion and low-swelling hydrogel dressing using alginate, which is non-adhesive to cells and skin tissue, CaCO3, and carbonated water. The alginate/CaCO3 solution rapidly formed a hydrogel upon the addition of carbonated water, and the CO2 in the hydrogel diffused into the atmosphere, preventing acidification and obtaining a pH value suitable for wound healing. Remarkably, the skin adhesion and swelling of the hydrogel were 11.9- to 16.5-fold and 1.9-fold lower, respectively, than those of clinical low-adhesion hydrogel dressings. In vivo wound-healing tests in mice demonstrated its therapeutic efficacy, and the prepared hydrogel prevented temporary wound dilation during early healing. These results illustrate the importance of controlling skin adhesion and swelling in wound dressings and demonstrate the potential clinical applications of this wound-friendly hydrogel dressing.
DOI	10.1016/j.ijbiomac.2023.127928