アリスエ　ノブコ   Arisue Nobuko   有末　伸子    所属   医学部 医学科    職種   助教
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Immune tolerance caused by repeated P. falciparum infection against SE36 malaria vaccine candidate antigen and the resulting limited polymorphism.
掲載誌名	正式名：Parasitology international 略　 称：Parasitol Int ISSNコード：18730329/13835769
掲載区分	国外
巻・号・頁	99,pp.102845
著者・共著者	Palacpac Nirianne Marie Q, Ishii Ken J, Arisue Nobuko, Tougan Takahiro, Horii Toshihiro
発行年月	2024/04
概要	The call for second generation malaria vaccines needs not only the identification of novel candidate antigens or adjuvants but also a better understanding of immune responses and the underlying protective processes. Plasmodium parasites have evolved a range of strategies to manipulate the host immune system to guarantee survival and establish parasitism. These immune evasion strategies hamper efforts to develop effective malaria vaccines. In the case of a malaria vaccine targeting the N-terminal domain of P. falciparum serine repeat antigen 5 (SE36), now in clinical trials, we observed reduced responsiveness (lowered immunogenicity) which may be attributed to immune tolerance/immune suppression. Here, immunogenicity data and insights into the immune responses to SE36 antigen from epidemiological studies and clinical trials are summarized. Documenting these observations is important to help identify gaps for SE36 continued development and engender hope that highly effective blood-stage/multi-stage vaccines can be achieved.
DOI	10.1016/j.parint.2023.102845
PMID	38101534