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ホンダ タカフミ
HONDA Takafumi
本田 隆文 所属 医学部 医学科（附属八千代医療センター） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Factors influencing the development of infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion |
| 掲載誌名 | 正式名：Journal of the neurological sciences 略 称：J Neurol Sci ISSNコード：0022510X/18785883 |
| 掲載区分 | 国外 |
| 出版社 | Elsevier B.V. |
| 巻・号・頁 | 457,pp.122904 |
| 著者・共著者 | Yasukohchi Madoka†, Omata Taku*, Ochiai Kenta, Sano Kentaro, Murofushi Yuka, Kimura Sho, Takase Nanako, Honda Takafumi, Yasukawa Kumi, Takanashi Jun-ichi |
| 発行年月 | 2024/02/15 |
| 概要 | Background: Infantile traumatic brain injury (TBI) with a biphasic clinical course and late reduced diffusion (TBIRD) has been reported as a type of TBI. However, it remains uncertain which pediatric patients with TBI develop TBIRD.
Methods: Patients with TBI who were admitted to our hospital and underwent magnetic resonance imaging (MRI) between December 2006 and October 2022 were included in this study. A diagnosis of TBIRD was made in patients with or suspected TBI, with initial symptoms being convulsions or disturbance of consciousness and late-onset subcortical reduced diffusion, the so-called bright tree appearance. Clinical features, neuroimaging (computed tomography (CT) and MRI) findings, laboratory data, and Tada score were retrospectively compared between TBIRD and non-TBIRD patients. Neurological prognosis was assessed using the Pediatric Cerebral Performance Category scale. Results: Of 21 patients who met the inclusion criteria, a diagnosis of TBIRD was made in 7 patients (median age: 8 months). The factors contributing to TBIRD development were seizures lasting over 30 min as the initial symptom (5/7 in TBIRD vs. 0/14 in non-TBIRD), tracheal intubation during initial treatment (5/7 vs. 0/14), and brain parenchymal lesions on CT (3/7 vs. 0/14), suggesting that severe TBI may progress to TBIRD. The Tada score was more positive in patients with TBIRD (6/7) than in those without (0/14). Conclusions: It is important to monitor infant patients with severe TBI for the development of TBIRD. The Tada score can be a useful tool for TBIRD prediction. |
| DOI | 10.1016/j.jns.2024.122904 |
| PMID | 38290378 |