フルイチ　ヨシヒロ   Furuichi Yoshihiro   古市　好宏    所属   医学部 医学科（附属足立医療センター）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Elucidation of spleen elasticity and viscosity in a carbon tetrachloride rat model of liver cirrhosis using a new ultrasound elastography.
掲載誌名	正式名：Journal of medical ultrasonics (2001) 略　 称：J Med Ultrason (2001) ISSNコード：16132254/13464523
掲載区分	国外
巻・号・頁	48(4),pp.431-437
著者・共著者	Furuichi Yoshihiro, Sugimoto Katsutoshi, Oshiro Hisashi, Abe Masakazu, Takeuchi Hirohito, Yoshimasu Yuu, Itoi Takao
発行年月	2021/10
概要	PURPOSE:Measurement of spleen stiffness (SS) using ultrasound (US) elastography is useful for predicting portal hypertension. However, the mechanism leading to increased SS remains unclear. We jointly developed a new US elastography system (Aplio i-series, Canon Medical Systems) that can easily measure organ viscosity (dispersion slope: DS). We analyzed the cause of increased SS by calculating the shear wave speed (SWs, which reflects fibrosis) and DS of the spleen in carbon tetrachloride (CCL4) rat liver cirrhosis models.METHODS:A total of 13 Sprague-Dawley rats were randomly divided into four groups (C group: 3 rats as control, 2D group: 3 rats injected with CCL4 twice in 1 week, 4D group: 4 rats injected 4 times in 1 week, 6W group: 3 rats injected twice a week for 6 weeks). The SWs and the DS of each group were calculated, and histopathological analysis was performed.RESULTS:The spleen SWs of the 6W group was significantly higher than that of the C group (p = 0.044). The spleen DS did not change after CCL4. The liver SWs of the 4D and 6W groups was significantly higher than that of the C group (p = 0.012 and 0.007, respectively) with fibrosis change on histopathology, and the DS of the 4D group was significantly higher than that of the C group (p = 0.033). Splenic fibrosis was confirmed in the 6W group, but inflammation and necrosis were not seen.CONCLUSION:SS increased due to fibrosis and can be predicted based on SWs and DS values.
DOI	10.1007/s10396-021-01110-5
PMID	34185192