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フルイチ ヨシヒロ
Furuichi Yoshihiro
古市 好宏 所属 医学部 医学科（附属足立医療センター） 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Viscoelasticity Measurement in Rat Livers Using Shear-Wave US Elastography. |
| 掲載誌名 | 正式名：Ultrasound in medicine & biology 略 称：Ultrasound Med Biol ISSNコード：1879291X/03015629 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 44(9),pp.2018-2024 |
| 著者・共著者 | Sugimoto Katsutoshi, Moriyasu Fuminori, Oshiro Hisashi, Takeuchi Hirohito, Yoshimasu Yu, Kasai Yoshitaka, Furuichi Yoshihiro, Itoi Takao |
| 発行年月 | 2018/09 |
| 概要 | To investigate the usefulness of shear-wave speed and dispersion slope measurements obtained, using an ultrasound elastography system in rat livers with various degrees of necroinflammation and fibrosis. A total of 25 male Sprague Dawley rats were randomly divided into 5 groups of 5 rats each: G0 (control), G1 (CCl4 injected twice a week for 1 wk), G2 (CCl4 injected four times a wk for 1 wk), G3 (CCl4 injected twice a wk for 6 wk) and G4 (CCl4 injected twice a wk for 10 wk). The shear-wave speed (m/s) and the dispersion slope ([m/s]/kHz) were measured. Histologic features (inflammation, necrosis and fibrosis) were used as reference standards. In multivariable analysis with histologic features as independent variables, the fibrosis grade was significantly related to shear-wave speed (p < 0.05) and the necrosis grade was significantly related to dispersion slope (p < 0.05). Dispersion slope is more useful than shear-wave speed for predicting the degree of necroinflammation. |
| DOI | 10.1016/j.ultrasmedbio.2018.05.008 |
| PMID | 29936025 |