コダマ　タカシ   Kodama Takashi   児玉　貴史    所属   医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The transcription factor Tbx5 regulates direction-selective retinal ganglion cell development and image stabilization.
掲載誌名	正式名：Current biology : CB 略　 称：Curr Biol ISSNコード：18790445/09609822
掲載区分	国外
巻・号・頁	32(19),pp.4286-4298.e5
著者・共著者	Al-Khindi Timour, Sherman Michael B, Kodama Takashi, Gopal Preethi, Pan Zhiwei, Kiraly James K, Zhang Hao, Goff Loyal A, du Lac Sascha, Kolodkin Alex L
発行年月	2022/10
概要	The diversity of visual input processed by the mammalian visual system requires the generation of many distinct retinal ganglion cell (RGC) types, each tuned to a particular feature. The molecular code needed to generate this cell-type diversity is poorly understood. Here, we focus on the molecules needed to specify one type of retinal cell: the upward-preferring ON direction-selective ganglion cell (up-oDSGC) of the mouse visual system. Single-cell transcriptomic profiling of up- and down-oDSGCs shows that the transcription factor Tbx5 is selectively expressed in up-oDSGCs. The loss of Tbx5 in up-oDSGCs results in a selective defect in the formation of up-oDSGCs and a corresponding inability to detect vertical motion. A downstream effector of Tbx5, Sfrp1, is also critical for vertical motion detection but not up-oDSGC formation. These results advance our understanding of the molecular mechanisms that specify a rare retinal cell type and show how disrupting this specification leads to a corresponding defect in neural circuitry and behavior.
DOI	10.1016/j.cub.2022.07.064
PMID	35998637