コダマ　タカシ   Kodama Takashi   児玉　貴史    所属   医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis.
掲載誌名	正式名：eLife 略　 称：Elife ISSNコード：2050084X/2050084X
掲載区分	国外
巻・号・頁	9,pp.58613
著者・共著者	Fujita Hirofumi, Kodama Takashi, du Lac Sascha
担当区分	2nd著者
発行年月	2020/07
概要	The cerebellar vermis, long associated with axial motor control, has been implicated in a surprising range of neuropsychiatric disorders and cognitive and affective functions. Remarkably little is known, however, about the specific cell types and neural circuits responsible for these diverse functions. Here, using single-cell gene expression profiling and anatomical circuit analyses of vermis output neurons in the mouse fastigial (medial cerebellar) nucleus, we identify five major classes of glutamatergic projection neurons distinguished by gene expression, morphology, distribution, and input-output connectivity. Each fastigial cell type is connected with a specific set of Purkinje cells and inferior olive neurons and in turn innervates a distinct collection of downstream targets. Transsynaptic tracing indicates extensive disynaptic links with cognitive, affective, and motor forebrain circuits. These results indicate that diverse cerebellar vermis functions could be mediated by modular synaptic connections of distinct fastigial cell types with posturomotor, oromotor, positional-autonomic, orienting, and vigilance circuits.
DOI	10.7554/eLife.58613
PMID	32639229