コダマ　タカシ   Kodama Takashi   児玉　貴史    所属   医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.
掲載誌名	正式名：Developmental cell 略　 称：Dev Cell ISSNコード：18781551/15345807
掲載区分	国外
巻・号・頁	52(4),pp.477-491.e8
著者・共著者	Ramos Susana I, Makeyev Eugene V, Salierno Marcelo, Kodama Takashi, Kawakami Yasuhiko, Sahara Setsuko
発行年月	2020/02
概要	Most adult neurons and glia originate from radial glial progenitors (RGs), a type of stem cell typically extending from the apical to the basal side of the developing cortex. Precise regulation of the choice between RG self-renewal and differentiation is critical for normal development, but the mechanisms underlying this transition remain elusive. We show that the non-canonical tubulin Tuba8, transiently expressed in cortical progenitors, drives differentiation of RGs into apical intermediate progenitors, a more restricted progenitor type lacking attachment to the basal lamina. This effect depends on the unique C-terminal sequence of Tuba8 that antagonizes tubulin tyrosination and Δ2 cleavage, two post-translational modifications (PTMs) essential for RG fiber maintenance and the switch between direct and indirect neurogenesis and ultimately distinct neuronal lineage outcomes. Our work uncovers an instructive role of a developmentally regulated tubulin isotype in progenitor differentiation and provides new insights into biological functions of the cellular tubulin PTM "code."
DOI	10.1016/j.devcel.2020.01.036
PMID	32097653