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ホンダ ゴロウ
HONDA Gorou
本田 五郎 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | The Outcome of Salvage Liver Transplantation and Liver Resection for Recurrent Hepatocellular Carcinoma Using the 5-5-500 Rule, Japanese Extended Liver Transplantation Criteria for Hepatocellular Carcinoma |
| 掲載誌名 | 正式名：Transplantation proceedings 略 称：Transplant Proc ISSNコード：18732623/00411345 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 55(4),pp.901-905 |
| 著者・共著者 | HIRATA Yoshihiro, KOTERA Yoshihito, KATO Takaaki, ARIIZUMI Shunichi, KOGISO Tomomi, TOKUSHIGE Katsutoshi, HONDA Goro, EGAWA Hiroto |
| 担当区分 | 最終著者 |
| 発行年月 | 2023/05 |
| 概要 | BACKGROUND:Liver transplantation (LT) for hepatocellular carcinoma (HCC) is limited to Child-Pugh class C patients according to the Japanese HCC treatment algorithm. However, extended criteria of LT for HCC, known as the 5-5-500 rule, were published in 2019. Hepatocellular carcinoma reportedly has a high recurrence rate after primary treatment. We hypothesized that the outcome of recurrent HCC would be improved if the 5-5-500 rule were adopted for patients with recurrent HCC. We, therefore, analyzed the outcomes of surgical treatment (liver resection [LR] and LT) for recurrent HCC using the 5-5-500 rule in our institute.METHODS:Fifty-two patients younger than 70 years of age received surgical treatment for recurrent HCC using our institute's 5-5-500 rule from 2010 to 2019. We divided these patients into the LR and LT groups in the first study. The 10-year overall survival and re-recurrence-free survival were analyzed. The second study analyzed the risk factors of re-recurrence after surgical treatment for recurrent HCC.RESULTS:In the first study, the background characteristics of the 2 groups (LR and LT) showed no significant difference, except for age and Child-Pugh classification. There was no significant difference in the overall survival between groups (P = .35), but the re-recurrence-free survival in the LR group was significantly shorter than that in the LT group (P < .01). In the second study, the male sex and LR were risk factors of re-recurrence after surgical treatment for recurrent HCC. Child-Pugh's class did not contribute to re-recurrence.CONCLUSIONS:To improve the outcomes of recurrent HCC, LT is the better choice, regardless of the Child-Pugh class. |
| DOI | 10.1016/j.transproceed.2023.04.028 |
| PMID | 37244836 |