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フクシマ ムネヒサ
Fukushima Munehisa
福嶋 宗久 所属 医学部 医学科（附属足立医療センター） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Impact of endolymphatic hydrops on the function of the horizontal canal during caloric stimulation in Ménière's disease. |
| 掲載誌名 | 正式名：European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 略 称：Eur Arch Otorhinolaryngol ISSNコード：14344726/09374477 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.08272 |
| 著者・共著者 | Fukushima Munehisa, Kadowaki Seiichi, Nakatani Saho, Waki Sadanori, Matsumoto Ken, Okamoto Hidehiko |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2023/10 |
| 概要 | PURPOSE:When a dizzy patient with episodic vertigo has an abnormal caloric and a normal video head impulse test (vHIT), this caloric-vHIT dissociation provides vital information for a diagnosis of Ménière's disease (MD). Endolymphatic hydrops (EH), a histological marker of MD, is hypothesized to be involved in the caloric-vHIT dissociation in MD through hydropic duct distension of the horizontal semicircular canal (SC). This study was designed to determine the impact of EH on the function of horizontal SC during caloric stimulation.METHODS:Caloric test and vHIT were used to evaluate the function of horizontal SC every six months, annual magnetic resonance imaging (MRI) was used to evaluate the degree of EH size in the vestibule, and monthly vertigo and hearing evaluation was done for 12 months. EH shrinkage was defined as the size change of vestibular EH from significant to none.RESULTS:Among 133 MD patients evaluated for eligibility, 67 patients with caloric-vHIT dissociation entered the study. Fifteen participants had EH shrinkage (G-I), while 52 participants had no remarkable EH change (G-II). Average values (IQR) of the maximum slow phase velocity in G-I and G-II were 29.6 (13.0-34.0) and 25.9 (17.3-31.3), respectively, at baseline, 26.1 (9.0-38.0) and 23.6 (18.0-28.3) at 12 months. Two-factor repeated-measures ANOVA showed no significant differences between the groups (P = 0.486). The values of vestibulo-ocular reflex gain of the horizontal SC in G-I and G-II remained above 0.8 during the study period.CONCLUSIONS:EH detected by MRI shows limited correlation with caloric stimulation results. |
| DOI | 10.1007/s00405-023-08272-7 |
| PMID | 37804352 |