フクシマ　ムネヒサ   Fukushima Munehisa   福嶋　宗久    所属   医学部 医学科（附属足立医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment.
掲載誌名	正式名：Laryngoscope investigative otolaryngology 略　 称：Laryngoscope Investig Otolaryngol ISSNコード：23788038/23788038
掲載区分	国外
巻・号・頁	2(6),pp.344-350
著者・共著者	Fukushima Munehisa, Kitahara Tadashi, Oya Ryohei, Akahani Shiro, Inohara Hidenori, Naganawa Shinji, Takeda Noriaki
担当区分	筆頭著者,責任著者
発行年月	2017/12
概要	OBJECTIVE/HYPOTHESIS:Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.STUDY DESIGN:Prospective, single-arm repeated measures.METHODS:Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.RESULTS:The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.CONCLUSION:EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.LEVEL OF EVIDENCE:2b.
DOI	10.1002/lio2.115
PMID	29299506