ワカバヤシ　ヒデタカ   Wakabayashi Hidetaka   若林　秀隆    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Diagnosis and outcomes of cachexia in Asia: Working Consensus Report from the Asian Working Group for Cachexia.
掲載誌名	正式名：Journal of cachexia, sarcopenia and muscle 略　 称：J Cachexia Sarcopenia Muscle ISSNコード：21906009/21905991
掲載区分	国外
巻・号・頁	pp.1
国際共著	国際共著
著者・共著者	Arai Hidenori, Maeda Keisuke, Wakabayashi Hidetaka, Naito Tateaki, Konishi Masaaki, Assantachai Prasert, Auyeung Wai Tung, Chalermsri Chalobol, Chen Wei, Chew Justin, Chou Ming-Yueh, Hsu Chih-Cheng, Hum Allyn, Hwang In Gyu, Kaido Toshimi, Kang Lin, Kamaruzzaman Shahrul Bahyah, Kim Miji, Lee Jenny Shun Wah, Lee Wei-Ju, Liang Chih-Kuang, Lim Wee Shiong, Lim Jae-Young, Lim Yen Peng, Lo Raymond See-Kit, Ong Terence, Pan Wen-Harn, Peng Li-Ning, Pramyothin Pornpoj, Razalli Nurul Huda, Saitoh Masakazu, Shahar Suzana, Shi Han Ping, Tung Heng-Hsin, Uezono Yasuhito, von Haehling Stephan, Won Chang Won, Woo Jean, Chen Liang-Kung
発行年月	2023/09
概要	Chronic diseases often lead to metabolic disorders, causing anabolic resistance and increased energy consumption, which result in cachexia. Cachexia, in turn, can lead to major clinical consequences such as impaired quality of life, shortened life expectancy, and increased healthcare expenditure. Existing international diagnostic criteria for cachexia employ thresholds derived from Western populations, which may not apply to Asians due to differing body compositions. To address this issue, the Asian Working Group for Cachexia (AWGC) was initiated. The AWGC comprises experts in cachexia research and clinical practice from various Asian countries and aims to develop a consensus on diagnostic criteria and significant clinical outcomes for cachexia in Asia. The AWGC, composed of experts in cachexia research and clinical practice from several Asian countries, undertook three-round Delphi surveys and five meetings to reach a consensus. Discussions were held on etiological diseases, essential diagnostic items for cachexia, including subjective and objective symptoms and biomarkers, and significant clinical outcomes. The consensus highlighted the importance of multiple diagnostic factors for cachexia, including chronic diseases, either or both weight loss or low body mass index, and at least one of the following: anorexia, decreased grip strength (<28 kg in men and <18 kg in women), or elevated C-reactive protein levels (>5 mg/L [0.5 mg/dL]). The AWGC proposed a significant weight change of 2% or more over a 3-6 month period and suggested a tentative cut-off value of 21 kg/m2 for low body mass index in diagnosing cachexia. Critical clinical outcomes were determined to be mortality, quality of life as assessed by tools such as EQ-5D or the Functional Assessment of Anorexia/Cachexia Therapy, and functional status as measured by the Clinical Frailty Scale or Barthel Index, with significant emphasis on patient-reported outcomes. The AWGC consensus offers a comprehensive definit
DOI	10.1002/jcsm.13323
PMID	37667992