カワマタ　タカカズ   Kawamata Takakazu   川俣　貴一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	その他
言語種別	英語
査読の有無	査読なし
表題	A case of "genetically defined" radiation-induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma.
掲載誌名	正式名：Neuropathology : official journal of the Japanese Society of Neuropathology 略　 称：Neuropathology ISSNコード：14401789/09196544
掲載区分	国外
巻・号・頁	43(5),pp.425-428
著者・共著者	MASUI Kenta†, NITTA Masayuki, MURAGAKI Yoshihiro, KAWAMATA Takakazu, SATOMI Kaishi, MATSUSHITA Yuko, YOSHIDA Akihiko, ICHIMURA Koichi, TSUDA Masum, TANAKA Shinya, KOMORI Takashi
発行年月	2023/03/22
概要	Letter to the Editor Radiation-induced gliomas (RIGs), which occur in a previously irradiated region of the original tumor, represent a rare but well-characterized clinical entity. They are particularly represented as secondary malignancies after irradiation for medulloblastoma (MB) and acute lymphoblastic leukemia (ALL). Clinically well recognized, their genetic characteristics have remained unclear,1 but recent molecular studies revealed their unifying molecular signature for the receptor tyrosine kinase 1 (RTK1) glioblastoma (GBM) subtype.2, 3 We present a case of RIG that emerged 29 years after surgery and radiation for pilocytic astrocytoma (PA); the distinctive molecular features of RIGs enabled its differentiation from malignant transformation of PA. All methods and protocols related to human subjects were approved by each institution's review board ethics committee, and the investigations were carried out in accordance with each institution's review board-approved protocol and Declaration of Helsinki of 2013.
DOI	10.1111/neup.12903
PMID	36949717