ヤマグチ　シゲキ   Yamaguchi Shigeki   山口　茂樹    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Feasibility of the semi-opened method of specimen resection for a circumferential resection margin in rectal cancer surgery: a multicenter study.
掲載誌名	正式名：Surgery today 略　 称：Surg Today ISSNコード：14362813/09411291
掲載区分	国外
巻・号・頁	52(9),pp.1275-1283
著者・共著者	Takemasa Ichiro, Okuya Koichi, Okita Kenji, Ishii Masayuki, Ito Masaaki, Uehara Kay, Konishi Tsuyoshi, Yamaguchi Shigeki, Inomata Masafumi, Sugita Shintaro, Hasegawa Tadashi, Ochiai Atsushi, Sakai Yoshiharu, Watanabe Masahiko
発行年月	2022/09
概要	PURPOSE:A circumferential resection margin (CRM) > 1 mm is a surrogate marker of oncologic outcomes in rectal cancer patients. In Japan, because the mesentery is removed from the rectum, the CRM cannot be measured. This multicenter prospective study evaluates the feasibility of a resected specimen processing method that allows CRM measurement.METHODS:Fifty patients with rectal cancer were enrolled. Resected specimens were processed as previously reported. The primary outcomes were CRM measurement and the rate of CRM positivity. The secondary outcomes were the quality of total mesorectal excision, the possibility to visualize and sample the tumor, the number of harvested lymph nodes, and comparison between the pathological CRM and preoperative mesorectal fascia (MRF) involvement. This study was registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry under identification number UMIN000031735.RESULTS:The CRM was measurable in all patients and found to be positive in three (6%). We confirmed tumor localization, sampled the tumor, and measured the distal margin in all patients. A median of 20 lymph nodes were harvested. The concordance rate between preoperative MRF involvement and pathological CRM status was 90%.CONCLUSION:A semi-opened rectal specimen with transverse slicing is a feasible method for measuring the CRM.
DOI	10.1007/s00595-022-02481-z
PMID	35378663