キクチ　ノリコ   Kikuchi Noriko   菊池　規子    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Clinical Validation of a Neointima-Inducing Inflow Cannula in a Continuous Flow Left Ventricular Assist Device.
掲載誌名	正式名：ASAIO journal (American Society for Artificial Internal Organs : 1992) 略　 称：ASAIO J ISSNコード：1538943X/10582916
掲載区分	国外
巻・号・頁	69(3),pp.299-303
著者・共著者	Yamada Yukiko†, Kikuchi Noriko, Yoshizawa Saeko, Ichihara Yuki, Hattori Hidetoshi, Saito Satoshi, Nunoda Shinichi, Niinami Hiroshi
発行年月	2023/03
概要	Wedge thrombus formation around the inflow cannula of a continuous left ventricular assist device (LVAD) is a source of systemic thromboemboli. We previously reported the potential advantages of a new inflow cannula wrapped with titanium mesh (GU30) over the standard smooth surface oblique cut cannula (GU10). The objective of the present study was to clinically validate this new cannula. A retrospective cohort analysis of patients with implanted LVAD (EVAHEART) comparing the GU10 to the GU30 was conducted. Clinical outcomes, including survival, the incidence of thromboembolism, and bleeding events, were compared. Gross and histopathological analyses of explanted GU30 cannula were conducted following transplant or patient death. No significant differences in the survival rate, severe emboli, or cerebral bleeding were observed during the LVAD implantation. However, severe emboli occurred earlier after LVAD implantation when using the GU30 cannula compared with the GU10. In cases of long LVAD support, the neointima fully covered the inflow of the GU30 cannulae without wedge thrombus formation. The titanium mesh-wrapped inflow cannulae did not reduce the overall incidence of neurological events significantly. However, the titanium mesh-wrapped inflow cannula induced autologous neointimal growth over the cannula and prevented wedge thrombus formation in late-phase LVAD implantation.
DOI	10.1097/MAT.0000000000001865
PMID	36729962