アリスエ　ノブコ   ARISUE Nobuko   有末　伸子    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	African-specific polymorphisms in Plasmodium falciparum serine repeat antigen 5 in Uganda and Burkina Faso clinical samples do not interfere with antibody response to BK-SE36 vaccination.
掲載誌名	正式名：Frontiers in cellular and infection microbiology 略　 称：Front Cell Infect Microbiol ISSNコード：22352988/22352988
掲載区分	国外
巻・号・頁	12,pp.1058081
著者・共著者	Arisue Nobuko†*, Palacpac Nirianne Marie Q, Ntege Edward H, Yeka Adoke, Balikagala Betty, Kanoi Bernard N, Bougouma Edith Christiane, Tiono Alfred B, Nebie Issa, Diarra Amidou, Houard Sophie, D'Alessio Flavia, Leroy Odile, Sirima Sodiomon B, Egwang Thomas G, Horii Toshihiro
担当区分	筆頭著者,責任著者
発行年月	2022/12/16
概要	BK-SE36, based on Plasmodium falciparum serine repeat antigen 5 (SERA5), is a blood-stage malaria vaccine candidate currently being evaluated in clinical trials. Phase 1 trials in Uganda and Burkina Faso have demonstrated promising safety and immunogenicity profiles. However, the genetic diversity of sera5 in Africa and the role of allele/variant-specific immunity remain a major concern. Here, sequence analyses were done on 226 strains collected from the two clinical trial/follow-up studies and 88 strains from two cross-sectional studies in Africa. Compared to other highly polymorphic vaccine candidate antigens, polymorphisms in sera5 were largely confined to the repeat regions of the gene. Results also confirmed a SERA5 consensus sequence with African-specific polymorphisms. Mismatches with the vaccine-type SE36 (BK-SE36) in the octamer repeat, serine repeat, and flanking regions, and single-nucleotide polymorphisms in non-repeat regions could compromise vaccine response and efficacy. However, the haplotype diversity of SERA5 was similar between vaccinated and control participants. There was no marked bias or difference in the patterns of distribution of the SE36 haplotype and no statistically significant genetic differentiation among parasites infecting BK-SE36 vaccinees and controls. Results indicate that BK-SE36 does not elicit an allele-specific immune response.
DOI	10.3389/fcimb.2022.1058081
PMID	36590593