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タカヤマ ユキコ
Takayama Yukiko
高山 敬子 所属 医学部 医学科（東京女子医科大学病院） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Evaluation of the Significance of Lymphatic, Microvascular and Perineural Invasion in Patients With Pancreatic Neuroendocrine Neoplasms. |
| 掲載誌名 | 正式名：Cancer diagnosis & prognosis 略 称：Cancer Diagn Progn ISSNコード：27327787/27327787 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 2(2),pp.150-159 |
| 著者・共著者 | IZUMO Wataru†, HIGUCHI Ryota, FURUKAWA Toru, YAZAWA Takehisa, UEMURA Shuichiro, MATSUNAGA Yutaro, SHIIHARA Masahiro, TAKAYAMA Yukiko, TAHARA Junko, SHIMIZU Kyoko, TOKUSHIGE Katsutoshi, YAMAMOTO Masakazu |
| 発行年月 | 2022 |
| 概要 | BACKGROUND:Some prognostic factors for pancreatic neuroendocrine neoplasms (PanNENs) have been reported; however, the significance of lymphatic, microvascular, and perineural invasion remains unclear. We aimed to clarify the role of these factors in PanNEN recurrence.PATIENTS AND METHODS:We analyzed 138 patients who underwent curative pancreatectomy and were pathologically diagnosed with PanNEN. We evaluated the association between clinicopathological factors and the recurrence of PanNENs.RESULTS:The numbers of patients with lymphatic, microvascular, and perineural invasion were 34 (25%), 43 (31%) and 17 (12%), respectively. Twenty-four patients (17%) had recurrences, and the 3, 5, and 10-year recurrence-free survival (RFS) rates were 88%, 84%, and 76%, respectively. The recurrence sites (with duplication) were mainly the liver (twenty-two patients), followed by the lymph nodes (seven patients), and bone (two patients). In multivariate analyses, grade 2-3 and the presence of microvascular invasion were significant risk factors for RFS (hazard ratio=7.5 and 7.9, respectively). When examining outcomes according to these factors, the 5-year RFS rates of patients with risk scores of 0, 1, and 2 were 100%, 91%, and 32%, respectively (p<0.001). Even in patients with grade 1 (n=97) or limited resection (enucleation, splenic-preserving distal pancreatectomy, central pancreatectomy, and duodenum-preserving pancreatic head resection, n=62), the presence of microvascular invasion was a significant risk factor for RFS (hazard ratio=13.4 and 18.0, respectively).CONCLUSION:The presence of microvascular invasion is an independent risk factor for recurrence in patients with PanNEN. |
| DOI | 10.21873/cdp.10089 |
| PMID | 35399168 |