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カナイ タカユキ
Kanai Takayuki
金井 貴幸 所属 医学部 医学科（東京女子医科大学病院） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | In silico comparison of the dosimetric impacts of a greater omentum spacer for abdominal and pelvic tumors in carbon-ion, proton and photon radiotherapy. |
| 掲載誌名 | 正式名：Radiation oncology (London, England) 略 称：Radiat Oncol ISSNコード：1748717X/1748717X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 14(1),pp.207 |
| 著者・共著者 | Yamada Masayoshi, Sato Hiraku, Ieko Yoshiro, Miyasaka Yuya, Kanai Takayuki, Yano Natsuko, Ono Takashi, Akamatsu Hiroko, Harada Mayumi, Ichikawa Mayumi, Teranishi Yasushi, Kikuchi Yasuhiro, Nemoto Kenji |
| 発行年月 | 2019/11 |
| 概要 | PURPOSE:The purpose of this study was to compare carbon-ion (C-ion), proton and photon radiotherapy (RT) plans with regard to dose reduction of the gastrointestinal (GI) tract by using a greater omentum spacer (GO spacer).METHODS:We retrospectively retrieved data for ten patients who received the GO spacer as surgical spacer placement for abdominal and pelvic tumors. Simulation plans were created on pre-spacer Computed Tomography (CT) and post-spacer CT for C-ion RT, proton RT and photon RT to compare the dose of the GI tract. The plans were normalized so that at least 95% of the planning target volume (PTV) received 70 Gy (relative biological effectiveness equivalent) delivered in 35 fractions. All plans were created with the lowest possible dose to the GI tract under conditions that meet the dose constraints for the PTV and spinal cord (maximum dose < 45 Gy). The part of the GI tract to be evaluated was defined as that most adjacent to the PTV. C-ion RT plans and proton RT plans were calculated by a spot scanning technique, and photon RT plans were calculated employing by fixed-field intensity-modulated radiation therapy.RESULTS:D2 cc and V10-70 of the GI tract were significantly lower on post-spacer plans than on pre-spacer plans for all three RT modalities. Regarding post-spacer plans, D2 cc of the GI tract was significantly lower on C-ion RT plans and proton RT plans than on photon RT plans (C-ion vs photon p = 0.001, proton vs photon p = 0.002). However, there was no significant difference between C-ion RT plans and proton RT plans for D2 cc of the GI tract (C-ion vs proton p = 0.992). In the photon RT plan for one patient, D2 cc of the GI tract did not meet < 50 Gy.CONCLUSIONS:The GO spacer shows a significant dose reduction effect on the GI tract. |
| DOI | 10.1186/s13014-019-1411-0 |
| PMID | 31752932 |