カナイ　タカユキ   Kanai Takayuki   金井　貴幸    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Evaluation of four-dimensional computed tomography (4D-CT)-based pulmonary ventilation: The high correlation between 4D-CT ventilation and (81m)Kr-planar images was found.
掲載誌名	正式名：Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 略　 称：Radiother Oncol ISSNコード：18790887/01678140
掲載区分	国外
巻・号・頁	119(3),pp.444-8
著者・共著者	Kanai Takayuki, Kadoya Noriyuki, Ito Kengo, Kishi Kazuma, Dobashi Suguru, Yamamoto Takaya, Umezawa Rei, Matsushita Haruo, Takeda Ken, Jingu Keiichi
担当区分	筆頭著者
発行年月	2016/06
概要	PURPOSE:To evaluate four-dimensional computed tomography (4D-CT)-derived pulmonary ventilation by comparing with (81m)Kr-gas ventilation (VRI). We also proposed two methods to improve the functional accuracy of 4D-CT ventilation images and evaluated these methods.METHODS AND MATERIALS:Eleven lung cancer patients with 4D-CT and VRI were analyzed. Hounsfield unit-based (VHU) and a Jacobian-based (VJac) 4D-CT ventilation images were calculated. They were evaluated by voxel-by-voxel spearman's rank correlation coefficient (r) between 4D-CT ventilation and VRI images. After applying an averaging ventilation method and a slope calculating method, correlations were also calculated.RESULTS:4D-CT ventilation showed the high correlation to VRI (r=0.875 with VHU). An averaging method brought significantly higher (p=0.012) correlations to nuclear medicine images with VHU. The improvement was not significant (p=0.619) with VJac. Slope calculating method improved the correlation with VHU and slightly worsened the correlation with VJac.CONCLUSIONS:The averaging method we proposed might be useful to improve 4D-CT ventilation images. We found good agreement between 4D-CT ventilation and nuclear medicine ventilation, indicating the high physiologic accuracy of 4D-CT ventilation.
DOI	10.1016/j.radonc.2016.04.030
PMID	27165614