サカイ　リヨウコ   Sakai Riyouko   酒井　良子    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Association between patient-reported outcomes and impairments in work and activity in patients with rheumatoid arthritis in clinical remission: a retrospective analysis using the IORRA database.
掲載誌名	正式名：Modern rheumatology 略　 称：Mod Rheumatol ISSNコード：14397609/14397595
巻・号・頁	Epub ahead of print,pp.-
著者・共著者	Sakai Ryoko, Tanaka Eiichi, Inoue Eisuke, Sato Minako, Tanaka Masaru, Ikari Katsunori, Yamanaka Hisashi, Harigai Masayoshi
担当区分	筆頭著者
発行年月	2022/09
概要	OBJECTIVES:To explore the patient-reported outcomes (PROs) associated with work productivity and activity impairment (WPAI) in patients with rheumatoid arthritis (RA) in clinical remission.METHODS:We enrolled patients with RA ≥18 years and with a simplified disease activity index (SDAI) ≤3.3 from the IORRA dataset collected in October 2017. Pain-visual analogue scale (VAS), patients' global assessment VAS, Japanese version of the Healthcare Assessment Questionnaire-Disability Index (J-HAQ), and duration of morning joint stiffness (MJS) were selected as PROs. To evaluate work productivity and activity, the WPAI-RA instrument (WPAI-RA) was used. To assess the contribution of each PRO to WPAI-RA score, an ANOVA model was constructed.RESULTS:The mean age of the 2,614 patients was 62.4 years; 85.1% were female. Median values of WPAI-RA score were 1.1% for absenteeism, 6.5% for presenteeism, 7.4% for work impairment, and 10.2% for activity impairment. MJS contributed the most to absenteeism (18.0%), while pain-VAS contributed the most to presenteeism (57.4%), work productivity loss (51.1%), and daily activity impairment (53.7%). J-HAQ was the second most contributing factor to presenteeism (17.4%), work productivity loss (16.3%), and daily activity impairment (26.0%).CONCLUSIONS:The pain-VAS and J-HAQ highly contributed to WPAI in patients with RA in clinical remission.
DOI	10.1093/mr/roac105
PMID	36094815