|
アカシ サダコ
AKASHI Sadako
明石 定子 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | A prospective analysis of two studies that used the 5-mm interval slices and 5-mm margin-free method for ipsilateral breast tumor recurrence after breast-conserving surgery without radiotherapy. |
| 掲載誌名 | 正式名：Breast cancer (Tokyo, Japan) 略 称：Breast Cancer ISSNコード：18804233/13406868 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 30(1),pp.131-138 |
| 著者・共著者 | Ohsumi Shozo, Nishimura Reiki, Masuda Norikazu, Akashi-Tanaka Sadako, Suemasu Kimito, Yamauchi Hideko, Tokunaga Eriko, Ikeda Tadashi, Nishi Tsunehiro, Hayashi Hiroto, Iino Yuichi, Takatsuka Yuichi, Ohashi Yasuo, Inaji Hideo |
| 発行年月 | 2023/01 |
| 概要 | BACKGROUND:Breast-conserving surgery with radiotherapy is one of standard treatments for early breast cancer. However, it is regarded as an option to treat elderly patients with small hormone receptor-positive breast cancer with breast-conserving surgery and hormone therapy without radiotherapy. We conducted two sequential prospective studies to examine the feasibility of breast-conserving surgery without radiotherapy since 2002 and present the results.PATIENTS AND METHODS:Primary female breast cancer patients who fulfilled the strict eligibility criteria were prospectively enrolled in two sequential studies named WORTH 1 and 2. The surgical materials were sliced in 5-mm intervals and all slices were examined microscopically. Postoperative radiotherapy was not allowed, but tamoxifen or anastrozole was administered for 5 years. Ipsilateral breast tumor recurrence (IBTR)-free survival was the primary outcome.RESULTS:The data of the two studies were combined (N = 321). The median follow-up period for IBTR was 94 months (4-192 months). Only three patients were treated with adjuvant chemotherapy. The 5- and 10-year IBTR-free rates were 97.0% and 90.5%, respectively. The age at operation and PR status affected IBTR rates independently. When we calculated IBTR-free rates of patients who were 65 years of age or older at the time of surgery and had PR-positive tumors, the 5- and 10-year IBTR rates were both 98.4%.CONCLUSIONS: Our "5-mm-thick slice and 5-mm free-margin" method may be effective to select patients who can be treated by breast-conserving surgery and hormone therapy without radiotherapy. |
| DOI | 10.1007/s12282-022-01406-5 |
| PMID | 36175750 |