コジマ　ミツアキ   Kojima Mitsuaki   小島　光暁    所属   その他 その他    職種   嘱託医師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Optimal target blood pressure in elderly with septic shock (OPTPRESS) trial: study protocol for a randomized controlled trial.
掲載誌名	正式名：Trials 略　 称：Trials ISSNコード：17456215/17456215
掲載区分	国外
巻・号・頁	23(1),pp.799
著者・共著者	Endo Akira, Yamakawa Kazuma, Tagami Takashi, Umemura Yutaka, Takahashi Kyosuke, Nagasawa Hiroki, Araki Yuichi, Kojima Mitsuaki, Sera Toshiki, Yagi Masayuki, Yamamoto Ryo, Takahashi Jiro, Nakane Masaki, Takeda Chikashi, Narita Chihiro, Kazuma Satoshi, Okura Hiroko, Takahashi Hiroyuki, Wada Takeshi, Tahara Shu, Matsuoka Ayaka, Masaki Todani, Shiraishi Atsushi, Shimoyama Keiichiro, Yokokawa Yuta, Nakamura Rintaro, Sageshima Hisako, Yanagida Yuichiro, Takahashi Kunihiko, Otomo Yasuhiro
発行年月	2022/09
概要	BACKGROUND:Hemodynamic stabilization is a core component in the resuscitation of septic shock. However, the optimal target blood pressure remains debatable. Previous randomized controlled trials suggested that uniformly adopting a target mean arterial pressure (MAP) higher than 65 mmHg for all adult septic shock patients would not be beneficial; however, it has also been proposed that higher target MAP may be beneficial for elderly patients, especially those with arteriosclerosis.METHODS:A multicenter, pragmatic single-blind randomized controlled trial will be conducted to compare target MAP of 80-85 mmHg (high-target) and 65-70 mmHg (control) in the resuscitation of septic shock patients admitted to 28 hospitals in Japan. Patients with septic shock aged ≥65 years are randomly assigned to the high-target or control groups. The target MAP shall be maintained for 72 h after randomization or until vasopressors are no longer needed to improve patients' condition. To minimize the adverse effects related to catecholamines, if norepinephrine dose of ≥ 0.1 μg/kg/min is needed to maintain the target MAP, vasopressin will be initiated. Other therapeutic approaches, including fluid administration, hydrocortisone use, and antibiotic choice, will be determined by the physician in charge based on the latest clinical guidelines. The primary outcome is all-cause mortality at 90 days after randomization.DISCUSSION:The result of this trial will provide great insight on the resuscitation strategy for septic shock in the era of global aged society. Also, it will provide the better understanding on the importance of individualized treatment strategy in hemodynamic management in critically ill patients.TRIAL REGISTRATION:UMIN Clinical Trials Registry; UMIN000041775. Registered 13 September 2020.
DOI	10.1186/s13063-022-06732-9
PMID	36153530