オオサワ　シゲヒト   Oosawa Shigehito   大澤　重仁    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reactions
掲載誌名	正式名：European polymer journal. ISSNコード：00143057/18731945
掲載区分	国外
巻・号・頁	88,pp.553-561
総ページ数	9
著者・共著者	Shigehito Osawa, Takehiko Ishii, Hiroyasu Takemoto, Kensuke Osada, Kazunori Kataoka
担当区分	筆頭著者
発行年月	2017/03/01
概要	Facile and quantitative method to introduce primary-amino group into the distal chain end of poly(2-substituted 2-oxazoline)s (POx)s, which have attracted progressive interest as platform polymers for various bio-functionality materials, was established here via two-step reactions; First, termination of cationic polymerization of 2-oxazoline using sodium azide as the end-capping reagent, followed by the conversion of the azido group to an amino group using triphenylphosphine (TPP) by the Staudinger reaction. The azido introduction step and the subsequent amino conversion step was accomplished within 1 h and 3 h, respectively, to ultimately obtain ω-amino-poly(2-ethyl-2-oxazoline) (PEtOx-NH2) with 96% functionality. The synthesized PEtOx-NH2 was subjected to ring-opening polymerization of Nε-trifluoroacetyl-l-lysine N-carboxy anhydride (Lys(TFA)-NCA) to successfully obtain the block copolymer PEtOx-b-PLys(TFA), which can be utilized as a platform polymer to develop polymer therapeutics, thus, demonstrating the versatility of the presently reported procedure for further functionalization of POx derivatives.
DOI	10.1016/j.eurpolymj.2016.11.029