オオサワ　シゲヒト   Oosawa Shigehito   大澤　重仁    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Influence of anchoring segments on methacrylate-based comb-type hydrophilic polymer segments coated on silica surfaces using the grafting-to method
掲載誌名	正式名：Colloid and Interface Science Communications 略　 称：Colloid & Inter. Sci. Commun. ISSNコード：2215-0382
掲載区分	国外
巻・号・頁	36,pp.1-5
総ページ数	5
著者・共著者	Shigehito Osawa, Masato Kashiwakura, Hiro Yamaguchi, Hidenori Otsuka
担当区分	筆頭著者,責任著者
発行年月	2020/05/01
概要	Owing to development of controlled radical polymerization, a coating of substrates with (meth)acrylate-based hydrophilic polymers has been widely utilized to construct a biocompatible interface. The polymer layers impart a non-fouling effect against proteins correlated to conformations of the polymer segments. For (meth)acrylate-based polymer coating, it is speculated that interaction between polymers and substrates cannot be negligible when describing the conformation because their main chains have a hydrophobic nature derived from the alkyl structure. Herein, we performed coating of silica nanoparticles (SiNPs) with poly(olygoethylenglycolmethacrylate) (pOEGMA) and observed the coated pOEGMA likely lied flat on the silica surface in aqueous milieu. Block copolymerization with an anchoring segment facilitated the pOEGMA domains to be free from the surface and promoted non-fouling property likely due to anchoring segments occupying adsorption sites for pOEGMA. These results indicated the anchoring segment plays an important role in the construction of the methacrylate-based polymer layers for a bio-interface.
DOI	10.1016/j.colcom.2020.100258