オオサワ　シゲヒト   Oosawa Shigehito   大澤　重仁    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	An interpenetrating polymer network hydrogel with biodegradability through controlling self-assembling peptide behavior with hydrolyzable cross-linking networks
掲載誌名	正式名：Materials Today Advances 略　 称：Mater. Today Adv. ISSNコード：2590-0498
掲載区分	国外
巻・号・頁	9(100131),pp.1-8
総ページ数	8
著者・共著者	Shohei Ishikawa, Kazutoshi Iijima, Daisuke Matsukuma, Michihiro Iijima, Shigehito Osawa, Hhidenori Otsuka
担当区分	責任著者
発行年月	2021/03/01
概要	Hydrogels are used as cell culture scaffolds for tissue engineering and regeneration. These hydrogel designs are inevitably complicated because favorable scaffolds should have stiffness to sustain alignment of the cells and mimic the structure of the extracellular matrix (ECM) in the targeted tissue. However, the incorporation of biodegradability, which is an essential property for practical applications, into complex hydrogels is not easily attained. Herein, we established a new concept for constructing biodegradable hydrogels with an interpenetrating polymer network (IPN) structure, composed of a covalent cross-linked network and peptide self-assembling networks, to solve this dilemma of selecting between the complicated structure and facile biodegradability. Assuming that the diffusion of the self-assembled peptides out of the IPN hydrogel would be facilitated by the disappearance of the covalent cross-linked networks with hydrolysis properties and RADA16 peptides as the self-assembling networks.This IPN hydrogel showed overall degradation, based on hydrolysis of the poly(DL-lactide) domain, and was more effective as a scaffold for culturing chondrocytes to form articular cartilage tissues compared with the IPN hydrogel without the poly(DL-lactide) domain, likely owing to the promotion of ECM deposition.These results verified our strategy of constructing a hydrogel with a complicated, but biodegradable, structure.
DOI	10.1016/j.mtadv.2021.100131