ホシノ　ジユンイチ   Hoshino Jiyun'ichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Long-term Effectiveness of a Primary Care Practice Facilitation Program for Chronic Kidney Disease Management: An Extended Follow-up of a Cluster-Randomized FROM-J Study.
掲載誌名	正式名：Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 略　 称：Nephrol Dial Transplant ISSNコード：14602385/09310509
掲載区分	国外
巻・号・頁	pp.doi: 10.1093/ndt/gfac041
著者・共著者	Imasawa Toshiyuki, Saito Chie, Kai Hirayasu, Iseki Kunitoshi, Kazama Junichiro James, Shibagaki Yugo, Sugiyama Hitoshi, Nagata Daisuke, Narita Ichiei, Nishino Tomoya, Hasegawa Hajime, Honda Hirokazu, Maruyama Shoichi, Miyazaki Mariko, Mukoyama Masashi, Yasuda Hideo, Wada Takashi, Ishikawa Yuichi, Tsunoda Ryoya, Nagai Kei, Okubo Reiko, Kondo Masahide, Hoshino Junichi, Yamagata Kunihiro
発行年月	2022/02
概要	BACKGROUND:Practice facilitation program by multidisciplinary care for primary care physicians is expected to improve chronic kidney disease (CKD) outcomes, but there is no clear evidence of its long-term effectiveness. We have previously performed a cluster-randomized controlled trial for 3.5 years (the FROM-J study) with two arms-group A without the program and group B with the program. We aimed to assess the long-term effectiveness of the practice facilitation program on CKD outcomes via an extended 10-year follow-up of the FROM-J study.METHODS:We enrolled patients who were in the FROM-J study. The primary composite endpoint comprised cardiovascular disease (CVD), renal replacement therapy initiation, and a 50% decrease in the eGFR. The secondary endpoints were survival rate, eGFR decline rate, and collaboration rate between primary care physicians and nephrologists.RESULTS:The occurrence of the primary composite endpoint tended to be lower in group B (group A: 27.1% vs. group B: 22.1%, p = 0.051). Furthermore, CVD incidence was remarkably lower in group B (group A: 10.5% vs. group B: 6.4%, p = 0.001). Although both mortality and the rate of eGFR decline were identical between both groups, the eGFR decline rate was significantly better in group B than in group A only in patients with stage G3a at enrollment (group A: 2.35±3.87 mL/min/1.73 m2/year vs. group B: 1.68±2.98 mL/min/1.73 m2/year, p = 0.02). The collaboration rate was higher in group B.CONCLUSIONS:The CKD practice facilitation program for primary care physicians reliably decreases CVD events and may reduce the progression of cases to end-stage kidney disease.
DOI	10.1093/ndt/gfac041
PMID	35195257