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ホシノ ジユンイチ
HOSHINO Jiyun'ichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Long-term clinical outcomes for patients with lower limb ischemia implanted with G-CSF-mobilized autologous peripheral blood mononuclear cells. |
| 掲載誌名 | 正式名：Atherosclerosis 略 称：Atherosclerosis ISSNコード：18791484/00219150 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 208(2),pp.461-6 |
| 著者・共著者 | Horie Takashi, Onodera Rie, Akamastu Makoto, Ichikawa Yukio, Hoshino Junichi, Kaneko Eiji, Iwashita Chikara, Ishida Akaru, Tsukamoto Tatsuo, Teramukai Satoshi, Fukushima Masanori, Kawamura Akio, |
| 発行年月 | 2010/02 |
| 概要 | BACKGROUND:Many studies have described the clinical effects of treating critical limb ischemia with granulocyte colony-stimulating factor-mobilized autologous peripheral blood mononuclear cells (M-PBMNC); however, there are no long-term data available on survival, limb salvage, or prognostic factors.METHODS:To investigate the long-term clinical outcomes of M-PBMNC implantation, we reviewed data for 162 consecutive patients with limb ischemia who were treated with M-PBMNC implantation at 6 hospitals between 2001 and 2006. A subset of 123 patients with homogenous clinical profiles was selected for prognostic factor analysis.RESULTS:Of the 162 patients, 50 died during the follow-up period. The median follow-up time for surviving patients was 26.4 months. The 2-year survival rate was 65% for the 140 patients with arteriosclerosis obliterans (ASO), and 100% for the 11, 4 and 7 patients with thromboangiitis obliterans (TAO), diabetic gangrene (DG) and connective tissue disease (CTD), respectively. The 1-year amputation-free rates for ASO, TAO, DG and CTD were 70%, 79%, 75% and 83%, respectively. Common serious adverse events included heart failure (15 cases), myocardial infarction (15 cases), serious infection (13 cases), stroke (10 cases), and malignant tumor (9 cases). Significant negative prognostic factors associated with overall survival were ischemic heart disease and collection of a small number of CD34-positive cells. Factors associated with time-to-amputation and amputation-free survival were a combination of Fontaine classification and lower limb gangrene, and history of dialysis.CONCLUSIONS:Collection of a small number of CD34-positive cells and ischemic heart disease were associated with a reduction in overall survival. |
| DOI | 10.1016/j.atherosclerosis.2009.07.050 |
| PMID | 19720375 |