ヤノ　コウイチロウ   YANO Kouichirou
  矢野　紘一郎
   所属   医学部 医学科（東京女子医科大学病院）
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Factors Associated with Change in SARS-CoV-2 Antibody Titers from Three to Six Months after the Administration of the BNT162b2 mRNA COVID-19 Vaccine among Healthcare Workers in Japan: A Prospective Study.
掲載誌名 正式名：Internal medicine (Tokyo, Japan)
略　 称：Intern Med
ISSNコード：13497235/09182918
掲載区分国内
巻・号・頁 61(8),pp.1139-1143
著者・共著者 Mochizuki Takeshi, Hori Takaki, Yano Koichiro, Ikari Katsunori, Okazaki Ken
発行年月 2022/04
概要 Objective We evaluated the change in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody titers from three to six months after the administration of the BNT162b2 vaccine among healthcare workers. Methods A total of 337 healthcare workers who received 2 doses of the BNT162b2 vaccine were included in this study. Factors associated with SARS-CoV-2 antibody titers at three and six months and the change in SARS-CoV-2 antibody titers between three and six months after vaccine administration were analyzed using a logistic regression analysis. Results The SARS-CoV-2 antibody titer at 3 months was 4,812.1±3,762.9 AU/mL in all subjects and was lower in older workers than in younger ones. The SARS-CoV-2 antibody titer at 6 months was 1,368.9±1,412.3 AU/mL in all subjects. The SARS-CoV-2 antibody titers that were found to be high at three months were also high at six months. The change in SARS-CoV-2 antibody titers from 3 to 6 months was -68.9%±16.1%. The higher SARS-CoV-2 antibody titers at three months showed a more marked decrease from three to six months than lower titers. Conclusion This study demonstrates that SARS-CoV-2 antibody titers at three months decreased with age and were associated with the antibody titers at six months and the change in titer from three to six months. Older individuals in particular need to be aware of the declining SARS-CoV-2 antibody titers at six months after the BNT162b2 vaccine. The results of this study may provide insight into COVID-19 vaccine booster strategies.
DOI 10.2169/internalmedicine.8902-21
PMID 35185050