オカモト　トシヒロ   Okamoto Toshihiro   岡本　俊宏    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Efficacy of oral myofunctional therapy in middle-aged to elderly patients with obstructive sleep apnoea treated with continuous positive airway pressure.
掲載誌名	正式名：Journal of oral rehabilitation 略　 称：J Oral Rehabil ISSNコード：13652842/0305182X
掲載区分	国外
巻・号・頁	48(2),pp.176-182
著者・共著者	SUZUKI Mayumi, OKAMOTO Toshihiro, AKAGI YUICHI, MATSUI Kentaro, SEKIGUCHI Haruki, SATOYA Natsumi, INOUE Yuji, TATSUTA Akihisa, HAGIWARA Nobuhisa
担当区分	2nd著者
発行年月	2021/02
概要	BACKGROUND:Oral myofunctional therapy (MFT) is an effective treatment for mild-to-moderate obstructive sleep apnoea (OSA) in middle-aged patients. However, few reports have described its use in elderly patients with moderate and severe OSA. Moreover, no studies have examined the relationship between changes in tongue pressure with MFT and the severity of OSA.OBJECTIVE:We conducted an interventional study using MFT to evaluate the effect of MFT on middle-to-senior-aged patients with moderate or severe OSA and compared changes in apnoea-hypopnea index (AHI) and tongue pressure.METHODS:Thirty-two OSA patients (≥45 years) treated with continuous positive airway pressure (CPAP) were included. MFT was performed in parallel with CPAP. Three days after CPAP discontinuation, polysomnographies were performed and tongue pressures were measured before and after MFT.RESULTS:Patients were 69.3 ± 1.5 years old. After 6 months of MFT, AHI decreased significantly from 34.7 to 29.0/h (P = .03), while tongue pressure significantly increased from 35.9 to 45.6 kPa (P < .01). Seven patients (22%), including 6 of the 12 patients with moderate OSA (50%), experienced successful CPAP discontinuation.CONCLUSIONS:MFT can be a useful intervention even among middle-aged to elderly patients with OSA. Increased tongue pressure may have contributed to the AHI improvement. Clinical trials: Trial registration at www.umin.ac.jp UMIN000027547.
DOI	10.1111/joor.13119
PMID	33080062