アリイズミ　シユンイチ   Ariizumi Shiyun'ichi   有泉　俊一    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	総説
言語種別	英語
査読の有無	査読なし
表題	Hepatocellular adenoma, approximately half and predominantly inflammatory subtype, in 38 Japanese patients with several differences in age, gender, and clinical background factors from Western populations.
掲載誌名	正式名：Hepatology research 略　 称：Hepatol Res ISSNコード：13866346/13866346
掲載区分	国外
巻・号・頁	51(3),pp.336-342
著者・共著者	Izu Asami, Sugitani Masahiko, Kinukawa Noriko, Matsumura Hiroshi, Ogawa Masahiro, Moriyama Mitsuhiko, Yamazaki Shintaro, Takayama Tadatoshi, Hano Hiroshi, Yao Takashi, Kanda Hiroaki, Suzuki Koyu, Hayashi Seisyu, Ariizumi Syunichi, Yamamoto Masakazu, Morishita Yukio, Matsumoto Koshi, Nakamura Naoya, Nakano Masayuki
発行年月	2021/03
概要	AIM:Hepatocellular adenoma (HCA) has a lower prevalence in Japan than in Western countries and HCA subtypes have been reported for only a few Japanese patients. We analyzed HCA subtype data 38 patients from 23 hospitals in Japan in order to examine character and difference between Western countries.METHODS:To confirm HCA and to analyze subtypes, we performed immunohistochemical examinations.RESULTS:Thirty-eight cases were found to have HCA without cirrhosis. The male/female ratio was 18/20. Ages ranged from 15 to 79 (average, 43.2) years. Male and elder patients are not rare, furthermore, most of elder patients are male. Glycogen storage disease, past history of medicament use, hepatitis B virus surface antigen-positivity, antihepatitis C virus -positivity, diabetes mellitus, obesity, lipid metabolism disorder and alcoholism were present in of 6, 8, 1, 1, 6, 6, 4, and 6 cases, respectively. As to HCA subtypes, HNF1alpha-inactivated HCA, beta-catenin activated HCA (b-HCA), inflammatory HCA (IHCA) and unclassified HCA (U-HCA) accounted for nine (23.7%), four (10.5%), 17 (44.7%) and eight (21.1%) cases, respectively. Two cases showed coexistence of HCA and hepatocellular carcinoma (HCC) at surgery, and another had HCC which had been detected 23 years after HCA diagnosis. The HCA subtype of one of the former cases was U-HCA, while the remaining two had b-HCA and U-HCA.CONCLUSIONS:In Japanese HCA cases, the proportions of U-HCA, male and elder cases were slightly higher than in Western countries, and most of elder patients were male. IHCA was however common regardless of race, and was assumed to be the predominant subtype of HCA.
DOI	10.1111/hepr.13613
PMID	33381872