シミズ　タツヤ   Shimizu Tatsuya   清水　達也    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A novel alveolar epithelial cell sheet fabricated under feeder-free conditions for potential use in pulmonary regenerative therapy
掲載誌名	正式名：Regenerative Therapy ISSNコード：2352-3204
掲載区分	国外
巻・号・頁	19,pp.113-121
著者・共著者	MITSUBOSHI shota†, HOMMA Jun, SEKINE Hidekazu*, TAKAGI Ryo, SHIMIZU Tatsuya, KANZAKI Masato
発行年月	2022/03
概要	Introduction Lung transplantation is the only effective treatment option for many patients with irreversible pulmonary injury, and the demand for lung transplantation is increasing worldwide and expected to continue to outstrip the number of available donors. Regenerative therapy with alveolar epithelial cells (AECs) holds promise as an alternative option to organ transplantation. AECs are usually co-cultured with mouse-derived 3T3 feeder cells, but the use of xenogeneic tissues for regenerative therapy raises safety concerns. Fabrication of AEC sheets under feeder-free conditions would avoid these safety issues. We describe a novel feeder-free method of fabricating AEC sheets that may be suitable for pulmonary regenerative therapy.
DOI	10.1016/j.reth.2022.01.005