イシハラ ヒロキ   Ishihara Hiroki
  石原 弘喜
   所属   医学部 医学科(東京女子医科大学病院)
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Predictive impact of prognostic nutritional index on pembrolizumab for metastatic urothelial carcinoma resistant to platinum-based chemotherapy.
掲載誌名 正式名:Anticancer research
略  称:Anticancer Res
ISSNコード:02507005/17917530
掲載区分国外
巻・号・頁 41(3),pp.1607-1614
著者・共著者 ISHIYAMA Yudai†, KONDO Tsunenori*, NEMOTO Yuki, KOBARI Yuki, ISHIHARA Hiroki, TACHIBANA Hidekazu, YOSHIDA Kazuhiko, HASHIMOTO Yasunobu, TAKAGI Toshio, IIZUKA Junpei, TANABE Kazunari
発行年月 2021/03
概要 BACKGROUND/AIM:We investigated the prognostic nutritional index (PNI), comprised of lymphocytes and albumin, as a potential prognosticator of metastatic urothelial carcinoma (mUC) patients receiving pembrolizumab.PATIENTS AND METHODS:Sixty-five patients were retrospectively enrolled and classified as low (<40) and high (≥40) based on pretreatment PNI. Progression-free survival (PFS), overall survival (OS) and response rates were evaluated.RESULTS:In the low PNI group, significantly shorter PFS and OS were observed. PNI was shown to be an independent predictor of PFS and OS in the multivariate analysis. C-index for both PFS and OS improved with the addition of PNI to the model described in the KEYNOTE-045 study. Significantly more patients experienced initial disease progression in the low PNI group.CONCLUSION:PNI is a useful predictor of prognosis and disease progression in mUC patients receiving pembrolizumab.
DOI 10.21873/anticanres.14922
PMID 33788756