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マルコ イチロウ
Maruko Ichirou
丸子 一朗 所属 医学部 医学科（東京女子医科大学病院） 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Subfoveal choroidal thickness after brolucizumab therapy for neovascular age-related macular degeneration: a short-term multicenter study. |
| 掲載誌名 | 正式名：Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 略 称：Graefes Arch Clin Exp Ophthalmol ISSNコード：1435702X/0721832X |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.--- |
| 著者・共著者 | Tamashiro Tamaki, Tanaka Koji, Itagaki Kanako, Nakayama Makiko, Maruko Ichiro, Wakugawa Sorako, Terao Nobuhiro, Onoe Hajime, Wakatsuki Yu, Ogasawara Masashi, Sugano Yukinori, Yamamoto Akiko, Kataoka Keiko, Izumi Takahiko, Kawai Moeko, Mori Ryusaburo, Sekiryu Tetsuju, Okada Annabelle A, Iida Tomohiro, Koizumi Hideki, |
| 発行年月 | 2022/01 |
| 概要 | BACKGROUND/PURPOSE:Observation of choroidal thickness after anti-vascular endothelial growth factor (VEGF) therapy may be important for the ideal management of neovascular age-related macular degeneration (AMD). This study investigated changes in subfoveal choroidal thickness (SCT) during loading doses of intravitreal injections of brolucizumab in eyes with neovascular AMD.METHODS:This study included 73 eyes of 72 patients with neovascular AMD at five university hospitals in Japan. All 73 eyes underwent three monthly 6.0 mg intravitreal injections of brolucizumab at baseline, 1 month, and 2 months. The SCT at 3 months was evaluated using optical coherence tomography.RESULTS:The 73 eyes were classified into the treatment-naïve group (43 eyes) and the switched group (30 eyes) that were switched from other anti-VEGF treatments. After three intravitreal injections of brolucizumab, SCT significantly decreased from 236.5 ± 98.8 µm at baseline to 200.4 ± 98.3 µm at 3 months (percent of baseline 84.7%, P < 0.001) in the treatment-naïve group. In the switched group, SCT also significantly decreased from 229.0 ± 113.2 μm at baseline to 216.9 ± 110.2 μm at 3 months (percent of baseline 94.7%, P = 0.039), although the decrease was not as marked compared to that of the treatment-naïve group.CONCLUSION:Intravitreal injections of brolucizumab for neovascular AMD significantly reduced the SCT in both the treatment-naïve and switched groups. Brolucizumab may cause significant anatomic changes in the choroid, particularly in treatment-naïve AMD eyes, possibly more than that previously reported for other anti-VEGF agents. |
| DOI | 10.1007/s00417-021-05517-1 |
| PMID | 35034215 |