シイハラ　マサヒロ   Shiihara Masahiro   椎原　正尋    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Comparison of Clinicopathological Features of Biliary Neuroendocrine Carcinoma with Adenocarcinoma.
掲載誌名	正式名：Digestive surgery 略　 称：Dig Surg ISSNコード：14219883/02534886
掲載区分	国外
巻・号・頁	38(1),pp.30-37
著者・共著者	SHIIHARA Kimihiro, HIGUCHI Ryota, FURUKAWA Toru, YAZAWA Takehisa, UEMURA Shuichiro, IZUMO Wataru, YAMAMOTO Masakazu
担当区分	筆頭著者
発行年月	2021/01
概要	OBJECTIVE:This study aimed to demonstrate the clinical features and postoperative outcomes of extrahepatic bile duct (EHBD) neuroendocrine carcinoma (NEC) and compared with those of adenocarcinoma.METHODS:We retrospectively analyzed patients with EHBD cancer operated in our institution between 1995 and 2015.RESULTS:Of 475 patients, 468 had adenocarcinoma, while 7 had NEC/mixed adenoneuroendocrine carcinoma (MANEC) in this study. There were no notable preoperative and pathological features in patients with NEC/MANEC. However, patients with NEC/MANEC had a higher recurrence rate (51.8 vs. 100%, p = 0.016), poorer relapse-free survival (RFS) time (the median RFS time: 35 vs. 12 months, p = 0.006), and poorer overall survival (OS) time (the median OS time: 60 vs. 19 months, p = 0.078) than those with adenocarcinoma. Furthermore, patients with NEC/MANEC had higher rates of liver metastasis (11.9 vs. 85.7%, p < 0.001) than those with adenocarcinoma. In multivariable regression analysis, pathological type with NEC/MANEC was a risk factor for poorer RFS (p = 0.022, hazard ratio: 6.09).CONCLUSIONS:Patients with NEC/MANEC have high malignant potential and poor outcomes. It is necessary to develop an effective approach and postoperative adjuvant treatment for patients with NEC/MANEC.
DOI	10.1159/000508443
PMID	32570243